A child born to an HIV-infected mother may have detectable antibody to HIV (due to transplacental transfer of maternal IgG) without infection. Seroreversion will occur as the amount of maternal antibody declines.
Criteria - all of the following:
(1) a pediatric patient born to an HIV-infected mother
(2) documented HIV-antibody negative following loss of maternal IgG antibody
(2a) >= 2 negative EIA tests performed at 6-18 months of age
(2b) >= 1 negative EIA tests performed after 18 months of age
(3) no other laboratory evidence of infection (see below)
(4) no evidence of an AIDS-defining condition
where:
• If viral detection testing is performed (HIV p24 antigen, HIV culture, HIV PCR), the patient does not have positive results on 2 or more separate occasions, with exclusion of cord blood as one of the samples.
• The criteria does not require a positive serologic test for HIV antibody following delivery, just that the mother is HIV-positive. However, it would be hard to be called a reverter if there is not a positive result to change from.
To read more or access our algorithms and calculators, please log in or register.
