When to suspect HIV type 2:
(1) a person who has lived or who traveled in West Africa
(2) a person with clinical HIV disease or unexplained immunosuppression but negative testing for HIV-1
(3) a sexual contact or offspring of a patient with known HIV-2
(4) positive screening EIA test to HIV-2
Confirmation of the diagnosis requires one or more of the following:
(1) PCR detection of HIV-2 proviral DNA
(2) sequencing of the HIV-2 integrase gene
(3) Western blot testing with HIV-2 gp36 WITH at least 1 high molecular weight glycoprotein (gp105, gp125, gp140)
Laboratory testing that is suspicious for HIV-2 include"
(1) Western blot testing with HIV-2 gp36 WITHOUT any high molecular weight glycoprotein (gp105, gp125, gp140)
(2) multispot reactivity for HIV-2
