British Isles Lupus Assessment Group (BILAG) developed an index for evaluating disease activity in patients with systemic lupus erythematosus (SLE). The index is based on several findings, each of which is categorized. The authors are from multiple universities in Great Britain.
Patient selection: initial clinical assessment
Severe manifestations:
(1) creatinine clearance < 50 mL per minute
(2) active urine sediment in uncentrifuged specimen (> 5 WBC per hpf OR > 5 RBC per hpf OR red blood cell casts, in the absence of urinary tract infection)
(3) active nephritis in renal biopsy
Other parameters:
(1) 24 hour urine protein in g per 24 hours
(2) protein by dipstick
(3) hypertension
(4) serum creatinine
|
Parameter |
Severe |
Moderate |
Mild |
|
24 hour urine protein |
> 1 gram |
0.51 to 1.0 gram |
<= 0.5 gram |
|
protein by dipstick |
3+ or 4+ |
1+ or 2+ |
trace |
|
hypertension |
accelerated |
NA |
> 140/90 |
|
serum creatinine |
NA |
NA |
> 130 µmol/L (1.47 mg/dL) |
Key findings for determining category A:
(1) 24 hour urine protein or protein by dipstick
(2) active urine sediment
(3) active nephritis
|
Severe |
Moderate |
Mild |
Status |
Category |
|
>= 2 AND at least 1 key finding |
NA |
NA |
current |
A |
|
>=1 AND not category A |
NA |
NA |
current |
B |
|
none |
any |
NA |
current |
B |
|
none |
none |
any |
current |
C |
|
none |
none |
none |
previous |
D |
|
none |
none |
none |
never |
E |
Purpose: To perform an initial assessment of renal function in a patient with systemic lupus erythematosus (SLE) using the BILAG criteria.
Specialty: Immunology/Rheumatology
Objective: severity, prognosis, stage, differential diagnosis and mimics, red flags, disease progression, prevention
ICD-10: M32,
