Panet-Raymond et al identified prognostic factors associated with overall survival for a woman with recurrent cancer in the ipsilateral breast. These can help to identify a woman who may benefit from more aggressive management. The authors are from McGill University, University of British Columbia, and other institutions in Canada.
Patient selection: woman with recurrent cancer in ipsilateral breast
Parameters:
(1) time to recurrence in months
(2) lymphovascular invasion of recurrence
(3) estrogen receptor (ER) status of recurrence
(4) histologic grade of the recurrence
(5) margin status of recurrence
|
Parameter |
Findings |
Points |
|
time to recurrence |
> 48 months |
0 |
|
|
<= 48 months |
1 |
|
lymphovascular invasion |
negative |
0 |
|
|
positive |
1 |
|
ER status |
positive |
0 |
|
|
negative |
1 |
|
histologic grade |
low (Grade 1 or 2) |
0 |
|
|
high (Grade 3) |
1 |
|
margin status |
negative |
0 |
|
|
close or positive |
1 |
number of prognostic factors =
= SUM(points for all 5 parameters)
Interpretation:
• minimum number of prognostic factors: 0
• maximum number of prognostic factors: 5
• Overall survival decreases with increases in the number of prognostic factors.
|
Number of Prognostic Factors |
Percent with 10 Year Overall Survival (from Recurrence) |
|
0 or 1 |
70% |
|
2 |
36% |
|
3 to 5 |
20% |
Purpose: To evaluate a woman with recurrent cancer in the ipsilateral breast based on the study of Panet-Raymond et al.
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
Objective: risk factors, selection
ICD-10: C50.0,
