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Clinical-Pathologic Scoring System (CPS and CPS+EG) of Jeruss et al for Evaluating a Woman with Breast Cancer After Neoadjuvant Therapy

Purpose: To evaluate a woman with breast cancer using the Clinical-Pathologic Scoring System plus tumor markers (CPS+EG) of Jeruss et al.

Description

Jeruss et al used a Clinical-Pathologic Scoring System (CPS) with additional tumor markers (CPS+EG) to evaluate outcomes in women with breast cancer who received neoadjuvant therapy. The authors are from University of Texas M.D. Anderson Cancer Center in Houston.


Patient selection: absence of distant metastases (Stage IV)

 

Parameters:

(1) clinical stage

(2) pathologic stage

(3) estrogen receptor status (E)

(4) nuclear grade (G)

 

Parameter

Finding

Points

clinical stage

I or IIA

0

 

IIB or IIIA

1

 

IIIB or IIIC

2

pathologic stage

0 or I

0

 

IIA or IIB

1

 

IIIA or IIIB

1

 

IIIC

2

estrogen receptor

positive

0

 

negative

1

nuclear grade

I or II (low or intermediate)

0

 

III (high grade)

1

 

total CPS score =

= SUM(points for clinical and pathologic staging)

 

total CPS+EG score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum CPS score: 4

• maximum CPS+EG score: 6

• The higher the score the worse the survival.

 

CPS+EG Score

5 Year Disease Specific Survival Rate

0

100%

1

98%

2

96%

3

88%

4

72%

5

57%

6

22%

 


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Specialty

Objective

ICD-10