Poynard et al developed a simple index to identify a patient with viral hepatitis C who probably has significant findings on histology. The authors are from the METAVIR and CLINIVIR study groups in France.
Parameters:
(1) age in years
(2) platelet count
|
Parameter |
Finding |
Points |
|
age of the patient in years |
< 30 years |
0 |
|
|
30 – 39.99 years |
1 |
|
|
40 – 49.99 years |
2 |
|
|
50 – 59.99 years |
3 |
|
|
60 – 69.99 years |
4 |
|
|
>= 70 years |
5 |
|
platelet count |
>= 225,000 per µL |
0 |
|
|
200,000 to 224,999 per µL |
1 |
|
|
175,000 to 199,999 per µL |
2 |
|
|
150,000 to 174,999 per µL |
3 |
|
|
125,000 to 149,999 per µL |
4 |
|
|
< 125,000 per µL |
5 |
AP index =
= (points for age) + (points for platelet count)
Interpretation:
• minimum AP index: 0
• maximum AP index: 10
• An AP index >= 6 indicates significant histologic findings (moderate to severe necroinflammatory lesions, septal fibrosis and/or cirrhosis).
• A patient with a score >= 6 probably can be managed without a liver biopsy but a liver biopsy may be necessary for a lower score.
Performance:
• The sensitivity for an index >= 6 was 52% with a specificity of 93%.
• The area under the ROC curve is 0.763 +/- 0.043.
Purpose: To evaluate a patient with viral hepatitis C using the AP index of Poynard et al.
Specialty: Gastroenterology, Infectious Diseases
Objective: risk factors, clinical diagnosis, including family history for genetics, laboratory tests, disease progression
ICD-10: B18.2,
