Parameters:
(1) age in years
(2) gender
(3) alpha-2 macroglobulin in g/L
(4) hyaluronic acid in µg/L
(5) serum total bilirubin in µmol/L
(6) GGT in U/L
|
Gender
|
Points
|
|
male
|
1
|
|
female
|
0
|
where:
• The normal reference ranges for the tests were not listed. The methods are listed on page 1868.
X =
= (0.7464 * (points for gender)) - (0.0249 * (age in years)) + (1.0039 * (alpha-2 macroglobulin)) + (0.0302 * (hyaluronic acid)) + (0.0691 * (total serum bilirubin)) - (0.0012 * (GGT)) - 4.185818
hepascore =
= 1 / (1 + EXP((-1) * X))
Interpretation:
• minimum score: 0
• maximum score: 1
• A score < 0.5 excluded significant fibrosis.
• A score >= 0.5 was associated with significant fibrosis.
• A score >= 0.84 was associated with cirrhosis.
Performance:
• For a score < 0.5 in excluding significant fibrosis, the sensitivity was 88% and specificity 74%.
• For a score >= 0.84 for identifying cirrhosis, the sensitivity was 71% and specificity 89%. A score < 0.84 had a negative predictive value for cirrhosis of 0.94-0.98.
• Looking at the box plots in Figure 2 page 1871 indicates that there is a lot of overlap between different levels of fibrosis, especially METAVIR F2.
