FIB-4 Score for Evaluating Hepatic Fibrosis in Patient with Chronic Viral Hepatitis C

 

Parameters:

(1) age in years

(2) platelet count in 10^9/L

(3) AST in IU/L

(4) ALT in IU/L

 

FIB-4 score =

= (age) * (AST) / ((platelet count) * SQRT(ALT))

 

Interpretation:

• The higher the score the greater the risk for significant fibrosis.

FIB-4 Score	Percent with F3-F4 Fibrosis
< 1.45	5%
1.45 to 3.25	27%
> 3.25	82%

 

Performance:

• Vallet-Pichard et al found the FIB-4 to be concordant with the FibroTest 92% of the time when the score was < 1.45 and 76% of the time when the score was > 3.25.

• The method of measuring the AST and ALT will affect performance.