Hennes et al reported criteria for the diagnosis of autoimmune hepatitis (AIH). The authors are from multiple institutions from around the world participating in the International Autoimmune Hepatitis Group.
Parameters:
(1) autoantibodies (LKM = liver-kidney microsomal antibodies; SLA = soluble liver antibodies; AMA = antimitochondrial antibodies)
(2) serum IgG concentration
(3) liver histology
(4) diagnosis of viral hepatitis
Parameter
Finding
Points
autoantibodies
LKM >= 1:40
2
SLA positive
ANA or SMA >= 1:80
ANA or SMA >= 1:40
1
other
0
serum IgG
normal
> 1.01 to 1.10 * ULN
> 1.10 * ULN
liver histology
hepatitis typical for AIH
hepatitis compatible with AIH
viral hepatitis
present
absent
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 8
• A score of 6 indicates probable AIH.
• A score of 7 or 8 indicates definite AIH.
Performance:
• The sensitivity is 88% and specificity 97% using a score >= 6.
• The sensitivity is 81% and specificity 99% using a score >= 7.
• The area under the ROC curve is 0.95.
To read more or access our algorithms and calculators, please log in or register.
Purpose: To evaluate a patient for autoimmune hepatitis using the criteria of Hennes et al.
Specialty: Gastroenterology, Immunology/Rheumatology
Objective: criteria for diagnosis
ICD-10: K75.4,
