Criteria for Autoimmune Hepatitis & Primary Biliary Cirrhosis (AIH-PBC) Overlap Syndrome

Purpose: To diagnose the autoimmune hepatitis and primary biliary cirrhosis (AIH-PBC) overlap syndrome based on the criteria of Chazouilleres et al.

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Evaluation

Are you evaluating a patient with liver disease?

Yes

Serum ALT

Upper limit of the normal reference range for serum ALT

Serum GGT

Upper limit of the normal reference range for serum GGT

Serum alkaline phosphatase

Upper limit of the normal reference range for serum alkaline phosphatase

Serum levels of IgG

Upper limit of the normal reference range for serum IgG

Does the patient have antibodies to smooth muscle?

Yes

Does the patient have antimitochondrial antibodies?

Yes

Select an appropriate answer for each finding seen in a liver biopsy

Periportal piecemeal necrosis

Periseptal piecemeal necrosis

Florid bile duct lesions

Results

Please fill out required fields.

Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of criteria for AIH identified

Number of criteria for PBC identified

Does the patient meet the criteria for AIH-PBC overlap syndrome?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Overlap Syndrome with Autoimmune Hepatitis and Cirrhosis or Sclerosing Cholangitis Predictive Factors
- Autoimmune Hepatitis Following Immunomodulating Therapy for Multiple Sclerosis
Clinical Diagnosis, Including Family History For Genetics
Laboratory Tests
- Types of Autoimmune Hepatitis
Other Testing
- Scoring System for Autoimmune Hepatitis
Criteria For Diagnosis
- Types of Autoimmune Hepatitis
- Simplified Criteria for the Diagnosis of Autoimmune Hepatitis
Severity, Prognosis, Stage
- Revised IAHG Scoring System for Autoimmune Hepatitis
- Scoring System for Autoimmune Hepatitis
Differential Diagnosis And Mimics, Red Flags
- Overlap Syndrome with Autoimmune Hepatitis and Cirrhosis or Sclerosing Cholangitis Predictive Factors
- Features of Autoimmune Hepatitis & Sclerosing Cholangitis Overlap (AIH-PSC) Syndrome

Monitoring

Complication Detection
- Autoimmune Hepatitis Following Immunomodulating Therapy for Multiple Sclerosis

Specialty

Gastroenterology
Immunology/Rheumatology

Objective

criteria for diagnosis
differential diagnosis and mimics
red flags

ICD-10

K75.4 - Autoimmune hepatitis
K74.3 - Primary biliary cirrhosis

Info

Purpose: To diagnose the autoimmune hepatitis and primary biliary cirrhosis (AIH-PBC) overlap syndrome based on the criteria of Chazouilleres et al.

Specialty: Gastroenterology, Immunology/Rheumatology

Objective: criteria for diagnosis, differential diagnosis and mimics, red flags

ICD-10: K75.4, K74.3,

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