Patients with multiple sclerosis have an increased rate of autoimmune disorders such as autoimmune hepatitis. Immunomodultating therapy for multiple sclerosis (MS) may be followed by clinical hepatitis.


Therapy for MS that has been followed by active autoimmune hepatitis:

(1) interferon beta

(2) pulse therapy with methylprednisolone

(3) glatiramer acetate

(4) natalizumab


Diagnostic features:

(1) presence of multiple sclerosis

(2) course of immunomodulating therapy

(3) subsequent development of an episode of acute hepatitis within days or weeks

(4) evidence of autoimmune hepatitis on biopsy and/or serum autoantibodies

(5) exclusion of viral hepatitis or other cause


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