Features of Autoimmune Hepatitis & Sclerosing Cholangitis Overlap (AIH-PSC) Syndrome

IAHG score, revised (enter from 0 to 23)

Does the patient have inflammatory bowel disease?

Is the serum ALT significantly elevated?

Is the serum gamma globulin level or IgG elevated?

Does the patient have a titer of ANA >= 1:40?

Does the patient have a titer of anti-SMA >= 1:40?

Is there biochemical evidence of cholestasis (elevated bilirubin, elevated alkaline phosphatase, etc)?

Does cholangiography show evidence of subtle or gross fibrotic strictures in large bile ducts?

• significant bile duct injury (vanishing ducts and/or concentric periductal fibrosis)?

• moderate to severe piecemeal (interface) hepatitis?

• lymphocyte rosetting?

• moderate to severe periportal or periseptal lymphoplasmacytic infiltrate?