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Features of Autoimmune Hepatitis & Sclerosing Cholangitis Overlap (AIH-PSC) Syndrome

Purpose:

To evaluate a patient with liver disease for features suggesting the AIH-PSC overlap syndrome.

Specialty:

Gastroenterology
Immunology/Rheumatology

Objective:

clinical diagnosis, including family history for genetics, differential diagnosis and mimics, red flags

ICD-10:

K75.4, K83.0

Description:

Some patients may show features of both autoimmune hepatitis and primary sclerosing cholangitis (AIH-PSC overlap syndrome). If a person with primary sclerosing cholangitis shows signs of a hepatitis, or if a person with autoimmune hepatitis appears cholestatic, then the AIH-PSC overlap syndrome should be considered.

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