Criteria for Paracetamol-Induced Fulminant Hepatic Failure

Purpose: To monitor a patient with paracetamol poisoning using serial morning prothrombin times as reported by Harrison et al.

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Evaluation

Are you monitoring a patient with paracetamol poisoning?

Yes

Is the PT of normal control plasma approximately 15 seconds?

Yes

PT on day 1

seconds

PT on day 2

seconds

PT on day 3

seconds

PT on day 4

seconds

PT on day 5

seconds

PT on day 6

seconds

PT on day 7

seconds

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Maximum PT in seconds

Did the PT rise between days 3 and 4?

Number of risk factors for fulminant hepatic failure and mortality

Is the patient at increased risk for fulminant hepatic failure?

Mortality rate based on prothrombin time alone

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Fulminant Hepatitis B | Prognostic Factors
- Risk Factors for Mortality in Patient with Paracetamol-Induced Fulminant Hepatic Failure
Clinical Diagnosis, Including Family History For Genetics
Imaging Studies
- Prognostic Formula for Patient with Acute Liver Failure
Laboratory Tests
Other Testing
Criteria For Diagnosis
Severity, Prognosis, Stage
Differential Diagnosis And Mimics, Red Flags

Therapy

Selection

Specialty

Gastroenterology

Objective

laboratory tests
criteria for diagnosis
severity
prognosis
stage
selection

ICD-10

T39.1 - Poisoning, 4-aminophenol derivatives
K72.0 - Acute and subacute hepatic failure

Info

Purpose: To monitor a patient with paracetamol poisoning using serial morning prothrombin times as reported by Harrison et al.

Specialty: Gastroenterology

Objective: laboratory tests, criteria for diagnosis, severity, prognosis, stage, selection

ICD-10: T39.1, K72.0,

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