Liver Injury Unit (LIU) Scoring System for Pediatric Acute Liver Failure (PALF)

Patient selection: pediatric patient with acute liver failure

Outcome: Poor outcome was death or liver transplant.

Parameters:

(1) peak total bilirubin in mg/dL

(2) peak prothrombin time in seconds

(3) peak INR

(4) peak ammonia in µmol/L

score 1 =

= (3.584 * (peak total bilirubin)) + (1.809 * (peak PT)) + (0.307 * (peak ammonia))

score 2 =

= (3.507 * (peak total bilirubin)) + (54.51 * (peak INR)) + (0.254 * (peak ammonia))

Interpretation:

• The higher the score the worse the prognosis.

• Evaluation of survival was based on quartiles.

NOTE: The captions to the figures in the original paper suggest that the figures were switched. The cutoffs with the figure do not match the text on page 4. In Lu et al 2013 the data in Figure 1A (score 2) is the same as Figure 3 in Lu et al 2008 Figure 3 (admission score using INR). The cutoffs for Figure 1B for Lu et al 2013 (admission score using INR) match Figure 2 (score 1) for Lu et al 2008.

Caption for Figure 1 goes with figure for Figure 3 for Lu et al 2008.

Caption for Figure 2 goes with figure for Figure 1.

Caption for Figure 3 goes with figure for Figure 2.

Caption for Figure 4 goes with figure for Figure 4.

Based on best guess: