Inclusion of a major artery within a radiation therapy field may be followed by delayed complications.
Types of radiation-induced injury:
(1) stenosis due to hyperplasia of intima, media, and/or adventitia
(4) ischemic necrosis in the arterial wall
(6) rupture with hemorrhage
(7) nodular widening and tortuosity
variable (renal, intestine, extremities)
Onset may be from 3 months to many years after the radiation therapy.
Factors affecting outcome:
(1) age of the patient at the time of exposure (more common if > 40 years of age; hypoplasia more common in infants)
(2) intensity of radiation exposure
(3) collateral circulation to end organ
(4) concurrent vascular disease (atherosclerosis, other)
(1) vascular disease unrelated to radiation therapy (pure atherosclerosis, etc.)
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Purpose: To evaluate a patient for delayed arterial changes following radiation therapy.
Specialty: Hematology Oncology, Cardiology
Objective: adverse effects