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The University of Texas M.D. Anderson Cancer Center's Tumor Score for Aggressive Lymphoma

Purpose: To estimate the prognosis for a patient with an aggressive lymphoma using the M.D. Anderson Cancer Center Tumor Score.

Description

The M.D. Anderson Cancer Center's Tumor Score can be used to evaluate the risk for a patient with an aggressive malignant non-Hodgkin's lymphoma at the time of presentation. This can help identify patients who may benefit from more aggressive therapy.


Parameters:

(1) Ann Arbor stage

(2) B-type symptoms

(3) tumor burden

(4) serum LDH

(5) serum beta-2-microglobulin

 

B-type symptoms: one or more of the following

(1) unexplained, recurrent or sustained fever, with temperature > 38°C

(2) drenching night sweats

(3) weight loss > 10% over the 6 months prior to diagnosis

 

"Bulky" disease - at least 1 of the following:

(1) 1 or more tumor masses >= 7 cm

(2) a mediastinal mass visible on a standing PA chest X-ray

 

Parameter

Finding

Points

Ann Arbor Stage

III or IV

1

 

I or II

0

B type symptoms

present

1

 

absent

0

bulky tumor burden

present

1

 

absent

0

serum LDH

>= 1.1 times the upper limit of normal  (ULN) reference range

1

 

< 1.1 times ULN

0

serum beta-2 microglobulin

>= 1.5 times the ULN

1

 

< 1.5 times the ULN

0

 

tumor score =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 5

• A low score is associated with a good prognosis while a high score is associated with a poor prognosis.

 

Score

Prognosis

0, 1 or 2

good

3, 4, or 5

poor

 


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Specialty

Objective

ICD-10