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Aggressive Phenotypic Features for Chromophobe Renal Cell Carcinoma

Purpose: To identify poor prognostic features for a patient with a chromophobe renal cell carcinoma as reported by Amin et al.

Description

Amin et al identified features of a chromophobe renal cell carcinoma associated with a more aggressive clinical course. A patient with one or more of these risk factors may benefit from more aggressive management. The authors are from Cedars-Sinai Medical Center in Los Angeles, Emory University, Henry Ford Hospital, the National Medical Center in Mexico City, and University Hospital Zurich.


 

Patient selection: chromophobe renal cell carcinoma

 

Parameters:

(1) sarcomatoid pattern

(2) pathologic T stage

(3) tumor necrosis

 

Parameter

Finding

Points

sarcomatoid change

absent

0

 

present

1

pT

pT1 or pT2

0

 

pT3 or pT4

1

tumor necrosis

none

0

 

microscopic or macroscopic

1

 

where:

• pT3 or pT4 involves perinephric extension, invasion into adjacent organs, extension into renal vein and/or extension into the inferior vena cava (direct tumor growth no longer organ confined).

 

number of risk factors =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• The risk for a poor prognosis increases with the number of risk factors present.

 


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Specialty

Objective

ICD-10