Chromophobe Renal Cell Carcinoma Diagnosis

Are you evaluating a carcinoma arising in the kidney?

Yes

Are most of the cells eosinophilic or pale?

Yes

Do some areas show a sarcomatoid component?

Yes

Do sections show alveolar, nested and/or sheetlike growth patterns?

Yes

Are binucleated or multinucleated cells relatively common?

Yes

Is the mitotic rate low in non-sarcomatoid areas?

Yes

Do cells show a zone of perinuclear clearing?

Yes

Does a Hale's colloidal iron show a diffuse, granular positivity?

Are immunostains positive for?

• parvalbumin?

Yes

• low molecular weight keratin (CAM 5.2, AE1)?

Yes

• high molecular weight keratin?

Yes

• EMA?

Yes

• vimentin?

Yes

• CD9?

Yes

Does electron microscopyshow numerous cytoplasmic microvesicles and mitochrondria?

Are the cells hypodiploid with loss of 1 or more chromosomes (1, 2, 6, 10, 13, 17, 21, and/or Y)?

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of features seen in a chromophobe renal cell carcinoma

Number of findings suggesting an alternative diagnosis

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Clear Cell Renal Cell Carcinoma Prognostic Factors
- Chances of Aggressive Carcinoma in Renal Tumor Removed By Partial Nephrectomy
Clinical Diagnosis, Including Family History For Genetics
- Aggressive Phenotypic Features for Chromophobe Renal Cell Carcinoma
Severity, Prognosis, Stage

Monitoring

Response To Therapy
- Prediction Model of Leibovich et al for Patients with Clear Cell Renal Cell Carcinoma After Radical Nephrectomy
- The Stage, Size, Grade and Necrosis (SSIGN) Score of Frank et al for Predicting Survival in a Patient with a Clear Cell Renal Cell Carcinoma
Disease Progression
- Chances of Aggressive Carcinoma in Renal Tumor Removed By Partial Nephrectomy

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Monitoring

Specialty

Objective

ICD-10

Diagnostic Features of a Chromophobe Renal Cell Carcinoma

Purpose: To determine if a carcinoma arising in the kidney is a chromophobe renal cell carcinoma.

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Monitoring

Specialty

Objective

ICD-10