Stem Cell Transplant Lung Disease | Medical Algorithm

The Periengraftment Respiratory Distress Syndrome (PERDS) is a form of acute lung injury that occurs shortly after a stem cell transplantation (SCT).

Patient affected: most often seen after an autologous transplant

Onset: within 5 to 7 days after the SCT

Clinical features:

(1) fever

(2) dyspnea

(3) hypoxemia

Imaging findings: bilateral interstitial infiltrates

Type of Stem Cell Transplant	Response to Therapy
autologous	favorable
non-myeloablative allogeneic SCT with in vivo T cell depletion	favorable
unmanipulated allogeneic SCT	unfavorable

The diagnosis involves exclusion of other causes of acute respiratory distress.

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Clinical Features of Periengraftment Respiratory Distress Syndrome (PERDS)