Cytotoxic Lung Injury Associated with Bleomycin

Age of the patient

Total amount of bleomycin given to the patient

Has the patient had concurrent radiation therapy to the thorax?

Has drug therapy been continued after the onset of respiratory symptoms?

• a dry, nonproductive cough?

• dyspnea?

• tachypnea?

• rales?

• cyanosis?

• hypoxemia with reduced PaO2?

• a restrictive pattern with reduced vital and total lung capacities?

• decreased diffusing capacity for carbon monoxide?

• diffuse linear densities, more severe in the lower lobes?

• a fine nodular pattern?

• an alveolar filling process (diffuse alveolar damage)?

• diffuse alveolar damage?

• organizing interstitial pneumonia?

• interstitial pulmonary fibrosis?