Cytotoxic Lung Injury Associated with Busulfan

Has the patient received a high cumulative dose of busulfan?

Months treated with busulfan therapy

Has the patient had concurrent radiation therapy to the thorax?

Has drug therapy been continued after the onset of respiratory symptoms?

• a dry, nonproductive cough?

• dyspnea?

• tachypnea?

• fever?

• rales?

• cyanosis?

• hypoxemia with reduced PaO2?

• a restrictive pattern with reduced vital and total lung capacities?

• decreased diffusing capacity for carbon monoxide?

• diffuse linear densities?

• a reticulonodular pattern?

• an isolated nodular pattern?

• a pleural effusion?

• an alveolar filling process (diffuse alveolar damage)?

• diffuse alveolar damage?

• cytological atypia in alveolar and bronchial epithelial cells?

• interstitial edema?

• organizing interstitial pneumonia?

• interstitial pulmonary fibrosis?