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Scoring System of Schneider et al for Predicting Survival in Women with Advanced Ovarian Cancer

Purpose: To use a scoring system based on data at presentation to predict survival in patients with advanced ovarian cancer (Stages III or IV).

Description

Schneider et al developed a scoring system can be used to estimate survival in women with advanced ovarian cancer. This uses 4 parameters determined at the time of presentation or initial surgery. The study was performed at Assaf Harofeh Medical Center in Israel.


Patient selection: Patients with Stage III or IV ovarian cancer were evaluated.

 

Parameters:

(1) gravidity

(2) tumor stage

(3) serum LDH in U/L

(4) serum CA-125 in U/mL

 

Parameter

Finding

Points

gravidity

<= 2 pregnancies

2

 

> 2 pregnancies

1

tumor stage

IIIA or IIIB

1

 

IIIC

2

 

IV

3

LDH

<= 240 U/L

1

 

> 240 and <= 600 U/L

4

 

> 600 U/L

6

CA-125

<= 100 U/mL

1

 

> 100 U/mL

4

 

score =

= SUM(points for the 4 parameters)

 

Interpretation:

• minimum score: 4

• maximum score: 15

• The higher the score, the lower the survival.

 

Score

LOG10

LOG10 - LOG10(4)

Estimated Survival in Months

4

0.602

0

63

5

0.699

0.097

55

6

0.778

0.176

45

7

0.845

0.243

38

8

0.903

0.301

33

9

0.954

0.352

26

10

1.000

0.398

23

11

1.041

0.439

17

12

1.079

0.477

15

13

1.114

0.512

10

14

1.146

0.544

6

15

1.176

0.574

3

estimated from Figure 5, page 549.

 

Limitations:

• The method and reference ranges for LDH and CA-125 are not given. To extend these findings to other institutions, the values would have to be correlated.


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Specialty

Objective

ICD-10