Rajavithi-Ovarian Cancer Predictive Score (R-OPS) of Yanaranop et al

Description

Yanaranop et al reported the Rajavithi-Ovarian Cancer Predictive Score (R-OPS) for evaluation of a woman with a pelvic mass. The score can help to identify a woman who may require more aggressive management. The authors are from Rajavithi Hospital in Bangkok and Khon Kaen University in Thailand.

Patient selection: adult woman with a pelvic mass

Parameters:

(1) menopausal status

(2) serum CA 125 in U/mL (Roche Cobas Elecsys)

(3) serum HE4 in pM/L (Roche Cobas Elecsys)

(4) ultrasound findings of a solid area in the ovary (versus completely cystic)

Parameter	Finding	Points for Logistic Regression Model
menopausal status	premenopausal	0
	postmenopausal	1.37
serum CA 125		0.74 * LN(CA 125)
serum HE4		0,88 * LN(HE4)
ultrasound solid area	no	0
	yes	2.48

X =

= SUM(points for all 4 parameters) - 10.2

probability of ovarian cancer =

= 1 / (1 + EXP((-1) * X))

Parameter	Finding	Points for R-OPS
menopausal status	premenopausal	1
	postmenopausal	3
serum CA 125		SQRT(CA 125)
serum HE4		SQRT(HE4)
ultrasound solid area	no	1
	yes	6

R-OPS =

= (points for menopausal status) * (points for ultrasound) * (points for CA 125) * (points for HE4)

Interpretation:

• A R-OPS score > 330 is associated with ovarian cancer.

Performance:

• The sensitivity was 0.94 and specificity 0.80.

• The area under the ROC curve was 0.93.

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Description

Specialty

Objective

ICD-10