Gedalia et al used a number of criteria to determine if a pediatric patient with sarcoidosis responded to therapy with methotrexate. The authors are from Children’s Hospital and Louisianna State University Medical Center in New Orleans.
Patient selection: pediatric patient with sarcoidosis receiving corticosteroids
Goal: tapering of corticosteroid therapy without exacerbation of findings
Response to methotrexate:therapy may be measured by:
(1) clinical severity (using a clinical severity score)
(2) change in biologic markers (hemoglobin, serum ACE activity)
(3) success in tapering of corticosteroids
For each measure the response may be:
(1) complete resolution
(2) improvement
(3) stable
(4) progression
Complete response would entail:
(1) complete resolution of clinical findings
(2) normalization of hemoglobin and serum ACE activity
(3) stable without corticosteroids
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