Mana et al listed findings that can be used to assess disease activity in sarcoidosis. The authors are from the University of Barcelona in Spain.
(1) erythema nodosum or skin granulomas
(2) polyarthralgia or polyarthritis
(3) respiratory symptoms (cough, dyspnea)
(7) parotid enlargement
(8) upper respiratory tract involvement
(9) neurologic symptoms
(1) elevated serum angiotensin-converting enzyme (ACE) concentration
(2) elevated serum calcium (> 10.5 mg/dL, or 2.62 mmol/L)
(1) mediastinal lymphadenopathy
(2) pulmonary infiltration
(3) increased liver uptake on gallium-67 scan
(1) positive Kveim test
(2) lymphocytic alveolitis (increased lymphocytes in bronchoalveolar lavage)
(3) decreased forced vital capacity (< 80% of predicted)
(4) decreased carbon monoxide diffusing capacity (< 80% of predicted)
Disease activity can be assessed based on change in any of the listed criteria.
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Purpose: To evaluate a patient with sarcoidosis for disease activity based on the criteria of Mana et al.
Objective: severity, prognosis, stage, disease progression