Yale Prognostic Score in Primary Biliary Cirrhosis

 

Findings associated with poor prognosis:

(1) jaundice

(2) weight loss

(3) hepatomegaly

(4) splenomegaly

(5) ascites

(6) bridging fibrosis or cirrhosis on liver biopsy

(7) cholestasis on liver biopsy

(8) periportal hepatocellular necrosis on liver biopsy

 

Parameters identified in multivariate analysis:

(1) age: older age unfavorable

(2) hepatomegaly at onset: unfavorable

(3) portal fibrosis without bridging fibrosis or cirrhosis: favorable

(4) serum bilirubin: favorable if low, unfavorable if high

 

 

Parameter	Finding	Value
hepatomegaly	present at onset	1
	absent at onset	0
liver biopsy	portal fibrosis without bridging fibrosis or cirrhosis	1
	bridging fibrosis or cirrhosis present	0
serum bilirubin	> 5.0 mg/dL	0.82
	1.5 - 5.0 mg/dL	0
	< 1.5 mg/dL	-0.73

 

prognostic score =

= (0.037 * (age in years)) + (0.74 * (hepatomegaly value)) - (1.34 * (portal fibrosis value) + (bilirubin value)

 

Interpretation:

• The lower the score the better.