Score for Diagnosis of Primary Biliary Cirrhosis (PBC)

Gender of the patient

Serum alkaline phosphatase

Upper limit of normal for serum alkaline phosphatase

Serum ALT

Upper limit of normal for serum ALT

Serum IgM

Upper limit of the normal reference range for IgM

Is the serum total cholesterol elevated?

Does the patient have antimitochondrial antibodies (AMA)?

Is the titer of ANA > 1:40?

Is the patient positive for HBsAg?

Is the patient have evidence of hepatitis C virus?

Is the patient positive for another viral marker?

Does the patient have a recent history of blood transfusion?

Daily alcohol intake

Does the patient have a first or second degree relative with PBC?

Does the patient have a first degree relative with an autoimmune disease?

Has the patient been diagnosed with an autoimmune disease?

Is chronic nonsuppurative destructive cholangitis seen on liver biopsy?

Are granulomas seen on liver biopsy?

Is the number of bile ducts in a portal tract reduced compared to the number of hepatic arteries (ratio < 0.8)?

Is bile duct degeneration seen on liver biopsy?

Is ductular proliferation with plasma cells seen on liver biopsy?

Is focal necrosis seen in the hepatic lobule on liver biopsy?

Is there evidence for another diagnosis seen on liver biopsy?

Is the patient positive for an autoantibody (anti-centromere antibody, SS-A, SS-B)?

Does the patient have HLA DR8?

Diagnosis made on imaging studies