Criteria:
(1) severe, progressive and irreversible disease with poor prognosis
(2) no or very limited therapeutic options, not amenable to organ transplantation
(3) requirements for long term intensive care with very poor quality of life (severe pain, severe complications, complete disability, etc.)
Conditions which may require palliative care:
(1) extreme prematurity
(2) severe cerebral palsy
(3) severe neurologic complications following hypoxia, infectious disease or other cause
(4) severe brain malformation (holoprosencephaly, etc.)
(5) advanced malignancy with poor prognosis
(6) severe and complex congenital or acquired heart disease
(7) severe, end-stage cystic fibrosis
(8) severe, end-stage AIDS
(9) severe and complex congenital or acquired gastrointestinal disorder
(10) severe epidermolysis bullosa
(11) severe immunodeficiencies
(12) severe, chronic end-stage respiratory failure
(13) severe, chronic end-stage renal disease
(14) end-stage muscular dystrophies
(15) severe, progressive metabolic disorder
(16) severe osteogenesis imperfecta
(17) severe genetic syndromes (trisomy, other)
