Ovarian Function Score (OFS) of Li et al for a Premenopausal Women with Breast Cancer and Chemotherapy-Associated Amenorrhea

Patient selection: premenopausal woman with breast cancer and chemotherapy-induced amenorrhea

Parameters:

(1) age in years

(2) FSH concentration in IU/L (Roche E170, Roche Diagnostics)

(3) estradiol (E2) concentration in pg/mL (Roche E170, Roche Diagnostics)

total score =

= (points for age) + (points for FSH) - (points for E2)

Interpretation:

• minimum score: -1

• maximum score: 2

• A score <= 1 is associated with preserved ovarian function.

• A score of 2 would be associated with loss of ovarian function.

Performance:

• The sensitivity was 95% and specificity 79%.

• The area under the ROC curve is 0.92.

Limitations:

• The methods for measuring FSH and estradiol would need to perform similar to the assays used in the study.