Factors Affecting Reduction in Sperm Count for Man Treated with Cyclophosphamide (Cytoxan)

 

Factors affecting the reduction in the sperm count after cyclophosphamide therapy:

(1) total dose of cyclophosphamide per square meter BSA

(2) time interval after therapy

 

total dose of cyclosphosphamide per square meter body surface area =

= (total cumulative dose in grams) / (body surface area in square meters)

Total Dose Cytoxan in g per square meter	Percent with Normal Sperm Counts
< 7.5	70%
>= 7.5	10%

 

where:

• The median total dose in the low dose group was 4.1 g per square meter.

 

The chances of recovery in the sperm count increase with lower total doses.

 

Time effects:

(1) the nadir in the sperm count is within 4 months after therapy

(2) if recovery occurs it will occur within 5 years after therapy