A premenopausal woman treated for cancer may experience premature ovarian failure. A number of findings in the ovary and serum can help to identify these women.
Evaluation: usually performed in the early follicular phase
Parameter
Finding Associated with Premature Ovarian Failure
ovarian volume
reduced; may be < 3 cubic cm
number of antral follicles
reduced
serum FSH
increases as reserve declines, with persistent elevation; may be affected by oral contraceptives
serum inhibin B
decrease parallels decline in egg supply
serum anti-Mullerian hormone (AMH)
decrease parallels decline in egg supply
These findings may occur in conjunction with clinical features of menopause:
(1) amenorrhea
(2) hot flashes
(3) night sweats
(4) vaginal dryness
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