NEOS Score of Balu et al for Predicting 1-Year Functional Status in a Patient with Anti-NMDA Receptor Encephalitis

Description

Balu et al reported the NEOS score for predicting the functional status of a patient with anti-NMDA receptor encephalitis. This can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Pennsylvania, University of Barcelona and Erasmus University Medical Center.

Patient selection: anti-NMDA (Anti-N-Methyl-D-Aspartate) receptor encephalitis

Outcome: modified Ranking scale >= 3 at 1 year (poor)

Parameters:

(1) ICU admission

(2) clinical improvement after 4 weeks of treatment

(3) treatment within 4 weeks of symptom onset

(4) brain MRI

(5) CSF WBC count per microliter

Parameter	Finding	Points
ICU admission	no	0
	yes	1
clinical improvement	no	1
	yes	0
treatment within 4 weeks	no (delayed)	1
	yes	0
brain MRI	normal	0
	abnormal	1
CSF WBC	<= 20 per µL	0
	> 20 per µL	1

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the greater the risk for poor functional status at 1 year.

Score	Percent with Poor Functional Status
0 or 1	3%
2	15%
3	30%
4 or 5	69%

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NEOS Score of Balu et al for Predicting 1-Year Functional Status in a Patient with Anti-NMDA Receptor Encephalitis

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