The dose of interferon alfa-2b should be adjusted if evidence of hematologic toxicity develops in a patient being treated for viral hepatitis C.
Parameters:
(1) white blood cell count (leukopenia)
(2) absolute neutrophil count (neutropenia)
(3) platelet count (thrombocytopenia)
Parameter
Reduce Dose 50%
Discontinue
WBC count
< 1,500 per µL
< 1,000 per µL
absolute neutrophil count
< 750 per µL
< 500 per µL
platelet count (adult)
< 50,000 per µL
< 25,000 per µL
platelet count (pediatric)
< 80,000 per µL
where:
• I used an age >=17 to indicate an adult in the implementation.
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Purpose: To adjust the dose of interferon alfa-2b for a patient with hepatitis C for hematologic toxicity.
Specialty: Infectious Diseases, Pharmacology, clinical, Gastroenterology
Objective: pharmacogenetics, dosage adjustments
ICD-10: B17.1, B18.2,
