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Chronic HBeAg-Positive Viral Hepatitis B Criteria for Treatment Response

Purpose: To evaluate the response to therapy shown by a patient with a chronic HBeAg-positive hepatitis B viral (HBV) infection.

Description

Mao et al listed criteria for response to therapy for chronic HBeAg-positive viral hepatitis B (HBV). The authors are from Xiamen University in Fujian Province, China.


 

Patient selection: HBeAg-positive HBV

 

Therapy: interferon-alpha

 

Parameters:

(1) serum ALT

(2) blood HBV DNA

(3) HBeAg

Serum ALT

HBV DNA

HBeAg

Response

normal

undetectable

negative

complete

normal

detectable at < 10^5 copies/mL

negative or positive

partial

any other

any other

any other

non-response

 

A complete or partial response is considered sustained if still present at 24 weeks after cessation of therapy.

 

If the patient had a response but abnormal findings returned after treatment stopped then it is a relapse (or reinfection).

 


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Specialty

Objective

ICD-10