Browne and Holland reported a number of situations when an anticytokine autoantibody should be suspected.
|
Situation |
Consider |
|
pulmonary alveolar proteinosis (PAP) |
anti-GM-CSF |
|
pure red cell aplasia in a patient receiving erythropoietin |
anti-erythropoietin |
|
Felty syndrome with neutropenia |
anti-G-CSF |
|
severe infection with absence of C-reactive protein (CRP) |
anti-IL6 (interleukin 6) |
|
unexpected infection in the absence of an immunodeficiency |
various |
|
cystic fibrosis with repeated infection |
anti-TNF |
|
thymoma |
anti-IL12 |
|
myasthenia gravis |
anti-IL12 |
|
autoimmune polyendocrinopathy with Candidiasis |
anti-IL17 or anti-IL22 |
|
systemic lupus erythematosus |
anti-TNF |
Anticytokine autoantibodies:
(1) may show a titer that waxes and wanes
(2) may change avidity
Purpose: To identify a patient who should be evaluated for anticytokine autoantibodies.
Specialty: Immunology/Rheumatology, Infectious Diseases
Objective: laboratory tests, criteria for diagnosis
ICD-10: M01, M02, M03,
