Browne and Holland reported a number of infections associated with the presence of certain anticytokine autoantibodies.
Anticytokine Autoantibody
Associated Infection
anti-GM-CSF (granulocyte monocyte colony stimulating factor)
Nocardia, Aspergillus, Histoplasma, Cryptococcus, Proteus
anti-interferon gamma
nontuberculous myobacteria
anti-interferon alpha
viral infection
anti-IL6 (interleukin 6)
Staphylococcus aureus
anti-IL17
mucocutaneous candidiasis
anti-IL22
anti-TNF (tumor necrosis factor)
Gram negative infection
The possibility of anticytokine autoantibodies should be considered in a person with an infection if:
(1) unusual pathogen or unusual severity or recurrent (suspicion for an immunodeficiency)
(2) absence of other explanation
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Purpose: To identify an infection associated with anticytokine autoantibodies.
Specialty: Immunology/Rheumatology, Infectious Diseases
Objective: laboratory tests, criteria for diagnosis
ICD-10: M01, M02, M03,
