Daily Warfarin Dosage Adjustment for Patient Receiving Long-Term Amiodarone Therapy

Purpose: To adjust the daily dose of warfarin for a patient being initiated on long-term amiodarone therapy.

Are you evaluating a patient on a stable oral warfarin regimen who requires amiodarone therapy?

Yes

Daily dose of warfarin

mg per day

Daily maintenance dose of amiodarone

Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Percent reduction in warfarin dose required to prevent excessive anticoagulation

Risk Factors
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation
- Algorithm of Dunn for the Perioperative Management of a Patient Receiving Oral Anticoagulation
Clinical Diagnosis, Including Family History For Genetics
- Warfarin (Coumadin) Resistance Testing
- Warfarin Resistance Associated with Poor Intestinal Absorption
Laboratory Tests
- Warfarin (Coumadin) Resistance Testing

Selection
- Algorithm of Dunn for the Perioperative Management of a Patient Receiving Oral Anticoagulation
Pharmacogenetics
- Regression Model of Wells et al for Predicting Warfarin Dose Using Pharmacogenetics
Dosage Calculations
Dosage Adjustments
Failure Handling And Therapy Escalation

Response To Therapy
- Warfarin (Coumadin) Resistance Testing
Adverse Effects
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation
Drug Levels
- Warfarin (Coumadin) Resistance Testing
Overdose And Reversal
- Warfarin (Coumadin) Resistance Testing
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation

Purpose: To adjust the daily dose of warfarin for a patient being initiated on long-term amiodarone therapy.

Specialty: Hematology Oncology, Clinical Laboratory, Clinical Pharmacology

Objective: drug interactions, dosage adjustments

ICD-10: I80, I81, I82,

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