| To identify risk factors for excessive anticoagulation in a patient being treated with warfarin as reported by Hylek et al.|
|Cardiovascular Diseases, Vascular Medicine, Clinical Pharmacology, Pharmaceutical Medicine|
|risk factors, dosage adjustments, failure handling and therapy escalation, adverse effects, overdose and reversal|
|I72, I81, I82, O88, T79.0, T79.1|
Hylek et al identified a number of factors associated with excessive warfarin effect. Failure to adjust the warfarin dose when these are present can result in significant bleeding. The authors are from Massachusetts General Hospital and Harvard Medical School.