Maestu et al developed a prognostic index for patients with small cell (oat cell) lung cancer using pretreatment variables. This can help identify patients who may require more aggressive management. The authors are from University Hospital "La Fe" in Valencia, Spain.
Parameters:
(1) serum LDH
(2) serum albumin
(3) absolute neutrophil count
(4) extended disease (metastatic disease, Table 1, page 548)
(5) ECOG performance score
|
Parameter |
Finding |
Points |
|
serum LDH |
<= 225 IU/L |
0 |
|
|
> 225 IU/L |
1 |
|
serum albumin |
> 3.4 g/dL |
0 |
|
|
<= 3.4 g/dL |
1 |
|
absolute neutrophil count |
<= 7,500 per µL |
0 |
|
|
> 7,500 per µL |
1 |
|
extended (metastatic) disease |
absent |
0 |
|
|
present |
1 |
|
ECOG performance |
0 or 1 |
0 |
|
|
2 to 4 |
1 |
where:
• The method and reference range for LDH were not given. However, the LDH was considered elevated, so in the implementation the upper limit of the reference range will be used as the cutoff.
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the worse the prognosis.
|
Total Score |
Prognostic Group |
Probability of 2 Year Survival |
|
0 or 1 |
good |
16% |
|
2 or 3 |
intermediate |
5% |
|
4 or 5 |
poor |
0% |
Purpose: To evaluate a patient with small cell (oat cell) lung cancer using the prognostic score of Maestu et al based on pretreatment variables.
Specialty: Hematology Oncology, Surgery, general, Pulmonology
Objective: severity, prognosis, stage, selection
ICD-10: C34.9,
