A patient with lung cancer may develop one or more paraneoplastic syndromes. These may appear some time before the tumor is diagnosed. The severity may parallel disease activity.


Paraneoplastic syndromes seen with lung cancer include:

(1) thrombocytosis

(2) leukocytosis or a leukemoid reaction

(3) eosinophilia

(4) thrombocytopenic purpura or disseminated intravascular coagulopathy (DIC)

(5) thrombophlebitis

(6) hypertichosis languinosa

(7) erythema gyratum repens

(8) erythema multiforme

(9) tylosis (formation of callus or thickening of the skin)

(10) erythroderma

(11) exfoliative dermatitis

(12) acanthosis nigricans

(13) Sweet syndrome

(14) pruritis and/or urticaria

(15) dermatomyositis

(16) polymyositis

(17) vasculitis

(18) systemic lupus erythematosus

(19) cachexia

(20) fever of unknown origin (FUO)

(21) lactic acidosis

(22) hyperuricemia

(23) glomerulonephritis with or without the nephrotic syndrome

(24) finger changes (hypertrophic osteoarthropathy, clubbing)

(25) subacute sensory neuropathy

(26) mononeuritis multiplex

(27) intestinal pseudo-obstruction

(28) Lambert-Eaton myasthenic syndrome

(29) central nervous system disorders including limbic encephalitis and cerebellar degeneration

(30) necrotizing myelopathy

(31) cancer-associated retinopathy

(32) syndrome of inappropriate ADH secretion (SIADH)

(33) hypercalcemia (parathyroid hormone-like)

(34) Cushing syndrome (ACTH-like)

(35) gynecomastia

(36) hypercalcitonemia

(37) hypoglycemia (insulin-like)

(38) hyperthyroidism

(39) carcinoid syndrome

(40) anemia unrelated to blood loss

(41) interleukin-6 (IL-6) syndrome


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