Sickle Cell Disease Adverse Effects - Predictors of Adverse Outcome

Are you evaluating a pediatric patient with sickle cell anemia?

Yes

Does the patient have ...

• low levels of hemoglobin F?

Yes

• the presence of alpha-thalassemia?

Yes

• leukocytosis?

Yes

• reticulocytosis?

Yes

• microcytic indices (decreased MCV)?

Yes

• elevated serum AST?

Yes

• an increased number of pocked red blood cells

Yes

• hypertension?

Yes

• a history of transient ischemic attacks?

Yes

• a history of strokes?

Yes

• a history of acute renal failure?

Yes

• frequent painful crises?

Yes

• a history of the acute chest syndrome?

Yes

Select the appropriate answer for each question

Hemoglobin

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of risk factors for

• pediatric death

• adult death

• stroke

• acute chest syndrome (ACS)

• painful crises

• avascular necrosis of bone

• leg ulcers

• sepsis

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Clinical Diagnosis, Including Family History For Genetics
- Severity Index of Wali et al for a Child with Sickle Cell Disease (SCD)
- Index of van den Tweel et al for Severity of Sickle Cell Disease (SCD) in a Pediatric Patient
Laboratory Tests
- Model of Miller et al for Predicting the Risk of Severe Complications in a Child with Sickle Cell Disease
Criteria For Diagnosis
- Index of van den Tweel et al for Severity of Sickle Cell Disease (SCD) in a Pediatric Patient
Severity, Prognosis, Stage
Complications

Societal Concerns

Economic Cost
- Factors for Hospital Readmission in Adult with Acute Sickle Cell Pain

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Societal Concerns

Specialty

Objective

ICD-10

Predictors of Adverse Outcome in Pediatric Patient with Sickle Cell Anemia

Purpose: To identify predictors for adverse outcomes in pediatric patients with sickle cell anemia.

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Societal Concerns

Specialty

Objective

ICD-10