The Cooperative Study of Sickle Cell Disease (CSSCD) identified a number of predictors for adverse outcome in pediatric patients with sickle cell disease.
Risk factors for death as an adult:
(1) acute anemia
(2) low levels of hemoglobin F
(3) acute renal failure
(4) frequent painful crises
(5) acute chest syndrome
Risk factors for pediatric death:
Risk factors for stroke:
(2) acute chest syndrome
(3) transient ischemic attack
(5) absence of alpha-thalassemia
Risk factors for acute chest syndrome:
Risk factors for painful crises:
Risk factors for avascular necrosis of bone:
(2) frequent painful crises
(3) presence of alpha-thalassemia
(4) decreased MCV (microcytic indices)
(5) elevated AST
Risk factors for leg ulcers:
(2) decreased hemoglobin F
(1) increased percent pock-marked RBCs
• A history of stroke, painful crises and acute chest syndrome should increase the risk for future recurrences.
Depressed levels of hemoglobin F is associated with:
(1) pediatric or adult death
(3) frequent painful crises
(4) leg ulcers
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Purpose: To identify predictors for adverse outcomes in pediatric patients with sickle cell anemia.
Specialty: Hematology Oncology, Clinical Laboratory, Genetics
Objective: risk factors, severity, prognosis, stage