Certain clinical findings may be either indications of an impending complication or precipitating factors for a complication in a patient with a sickling hemoglobinopathy. A patient with one or more of these risk factors may benefit from a more extensive evaluation and early intervention.


Factors that may precipitate sickling:

(1) dehydration

(2) hypoxia

(3) acidosis

(4) stress

(5) infection

(6) exposure to extremes of environmental temperature (either very hot or very cold)


Indicators of a complication

(7) fever

(8) chest pain

(9) abdominal pain

(10) shortness of breath

(11) severe headache

(12) focal weakness

(13) change in mental status


To read more or access our algorithms and calculators, please log in or register.