Prognostic Classification of Patients with Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin

Purpose: Purpose: To use cortisol levels before and after corticotropin stimulation to identify patients with septic shock at high risk for short-term mortality.

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Evaluation

Are you evaluating a patient with septic shock?

Yes

Baseline cortisol level

Serum cortisol at 30 minutes after IV injection of 0.25 mg corticotropin

Serum cortisol at 60 minutes after IV injection of 0.25 mg corticotropin

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Peak cortisol after corticotropin

Change between baseline and peak cortisol level

Prognostic group

Predicted 28 day mortality rate

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Clinical Diagnosis, Including Family History For Genetics
Laboratory Tests
Other Testing
- Quick SOFA (qSOFA) Score
Criteria For Diagnosis
Severity, Prognosis, Stage

Therapy

Selection
- Using a Short ACTH Stimulation Test to Identify Patients with Septic Shock Who Have Relative Adrenocortical Insufficiency
- Dopamine-Resistant Septic Shock
Pharmacogenetics
- Dopamine-Resistant Septic Shock
Failure Handling And Therapy Escalation

Monitoring

Disease Progression

Specialty

Critical Care
Emergency Medicine
Infectious Diseases

Objective

severity
prognosis
stage

ICD-10

A49.9 - Bacterial infection, unspecified
R57.2 - Septic shock

Info

Purpose: Purpose: To use cortisol levels before and after corticotropin stimulation to identify patients with septic shock at high risk for short-term mortality.

Specialty: Critical Care, Emergency Medicine, Infectious Diseases

Objective: severity, prognosis, stage

ICD-10: A49.9, R57.2,

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