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Criteria for Metabolic Response to Therapy Seen on PET Scan

Purpose: To determine the metabolic response to therapy seen in a non-small-cell lung cancer (NSCLC) on [18F]FDG PET scan.

Description

Kong et al listed criteria for metabolic response following therapy to a a non-small-cell lung cancer as seen on a positron emission tomography (PET) scan. The authors are from the University of Michigan and Veterans Affairs Health Center in Ann Arbor.


 

Patient selection: non-small-cell lung cancer (NSCLC)

 

Imaging study: PET scan using [18F] fluorodeoxyglucose (FDG)

 

Timing: at least 6 to 8 weeks after radiation therapy and 2 weeks after chemotherapy (to minimize FDG uptake in inflammation triggered by the therapy).

 

Measurements:

(1) pretreatment FDG uptake in the tumor in standard uptake units (SUV)

(2) FDG uptake in the tumor at follow-uo

(3) mean SUV uptake of the aortic arch

 

percent FDG uptake at followup compared to pretreatment uptake =

= (SUV at followup) / (SUV at pretreatment) * 100%

FDG Uptake at Followup

Ratio of FDG at Follow-Up to Pretreatment

Metabolic Status

< mean uptake of the aortic arch

NA

complete metabolic response (CMR)

>= mean uptake of the aortic arch

<= 70%

partial metabolic response (PMR)

>= mean uptake of the aortic arch

71 to 119%

stable metabolic disease (SMD)

>= mean uptake of the aortic arch

>= 120%

progressive metabolic disease (PMD)

 


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Specialty

Objective

ICD-10