Pharmacokinetic Test Dose to Detect Risk for Excessive Toxicity Prior to 5-Fluorouracil Therapy

Purpose: To identify a patient at increased risk for toxicity from 5-fluorouracil (5-FU) using a small test dose as reported by Bocci et al.

Info MyLikes MyPaths

Evaluation

Are you to determine if a patient is at risk for 5-FU toxicity?

Yes

Following a 250 mg per square meter trial dose

Half-life (beta phase) for 5-FU

hours

Total body clearance of 5-FU

liters per h per sq m

Time to peak for 5-FDHU

minutes

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of findings suggesting slow 5-FU metabolism

Should an alternative to 5-FU be used for chemotherapy?

Should an assay for peripheral blood monocyte DPD activity be performed?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Criteria For Diagnosis
- World Health Organization (WHO) Criteria for Tumor Response to Therapy
Severity, Prognosis, Stage
- World Health Organization (WHO) Criteria for Tumor Response to Therapy

Therapy

Options
- World Health Organization (WHO) Criteria for Tumor Response to Therapy
Selection
- World Health Organization (WHO) Criteria for Tumor Response to Therapy
Dosage Adjustments
- Irinotecan Dosage Adjustment for Colon Cancer and Hepatic Dysfunction

Monitoring

Response To Therapy
Disease Progression
- World Health Organization (WHO) Criteria for Tumor Response to Therapy

Specialty

Hematology Oncology
Surgery, general

Objective

risk factors
selection

ICD-10

T45.1 - Poisoning, antineoplastic and immunosuppressive drugs

Info

Purpose: To identify a patient at increased risk for toxicity from 5-fluorouracil (5-FU) using a small test dose as reported by Bocci et al.

Specialty: Hematology Oncology, Surgery, general

Objective: risk factors, selection

ICD-10: T45.1,

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