Criteria of Livneh et al for the Diagnosis of Familial Mediterranean Fever

Age at time of first attack

• a history of typical attacks with generalized peritonitis?

• a history of typical attacks with unilateral pleuritis?

• a history of typical attacks with pericarditis?

• a history of typical attacks with mono-arthritis of hip, knee or ankle?

• a history of typical attacks with fever alone?

• a history of incomplete attacks involving the abdomen?

• a history of incomplete attacks involving the chest?

• a history of incomplete attacks with monoarthritis?

• exertional leg pain?

• favorable response to a therapeutic trial of colchicine?

• a family history of Familial Mediterranean Fever?

• an appropriate ethnic origin (Arab, Turk, other)?

• attacks severe enough to require bed rest?

• attacks with spontaneous remission?

• symptom-free intervals between attacks?

• attacks with a transient inflammatory response?

• episodes of proteinuria and/or hematuria?

• a history of negative workups for abdominal pain (negative laparotomy, removal of a normal appendix)?

• consanguinity of parents?