medical decision support medical decision support
Sign In

Clinical Score of Settin et al for Familial Mediterranean Fever (FMF)

Purpose: To evaluate a patient for Familial Mediterranean Fever (FMF) using the clinical score of Settin et al.

Description

Settin et al used a clinical score to identify patients who may have Familial Mediterranean Fever (FMF). This can help identify patients who may benefit from mutation analysis. The authors are Mansoura University and Al-Azhar University in Egypt.


Parameters:

(1) family history

(2) consanguinity

(3) duration of each attack in days

(4) frequency of attacks

(5) fever in °C

(6) abdominal pain

(7) joint involvement

(8) chest pain

(9) myalgia

(10) history of operations

 

Parameter

Finding

Points

family history

negative

1

 

positive

2

consanguinity

absent

1

 

present

2

duration of each attack

< 3 days

1

 

3 to 5 days

2

 

> 5 days

3

frequency of attacks

< 10 per year

1

 

10 to 30 per year

2

 

> 30 per year

3

fever

none

1

 

<= 39°C

2

 

> 39°C

3

abdominal pain

negative

1

 

moderate (does not interfere with activities)

2

 

severe (interferes with activities)

3

joint involvement

none

1

 

arthralgias

2

 

arthritis

3

chest pain

none

1

 

moderate (does not interfere with activities)

2

 

severe (interferes with activities)

3

myalgia

none

1

 

moderate (does not interfere with activities)

2

 

severe (interferes with activities)

3

history of operation

negative

1

 

positive

2

 

total score =

= SUM(points for all 10 parameters)

 

Interpretation:

• minimum score: 10

• maximum score: 27

• The higher the score the more likely the diagnosis of FMF.

• The diagnosis can be confirmed by demonstration of mutations in the MEFV gene on the short arm of chromosome 16 (using amplification refractory mutation system based on the polymerase chain reaction, or ARMS-PCR).

 

Total Score

Diagnosis of FMF

< 15

unlikely

15 to 20

probable

> 20

definite

 


To read more or access our algorithms and calculators, please log in or register.

Specialty

Objective

ICD-10