Criteria for Post-Irradiation Bone Sarcoma

Criteria of Brady (1979)

Criteria of Cahan (1948)

no microscopic or roentgenographic evidence of abnormalities in the bone at the time of radiation therapy

histologic or radiologic evidence of nonmalignant nature of initial bone problem

radiation applied in significant dosage to the field at which the sarcoma subsequently develops (> 1,100 rets)

lesion must arise in irradiated area

a relatively long, symptom free latent period (median 11 years)

5 year latency period required

microscopic evidence of sarcoma

histologic proof of carcinoma

no exposure to known carcinogen or co-carcinogen