Salmon et al developed a prognostic score for adults with astrocytic tumors. This can help identify patients who may benefit from more aggressive management. The authors are from Erasmus Hospital and the Free University of Brussels in Belgium.
Patients ranged from 16 to 82 years of age.
Parameters:
(1) age of the patient (prognosis worse with older age)
(2) histolopathologic grade
(3) DNA histogram type
Histopathologic Type
Grade for Score
low grade astrocytic tumor
1
high grade astrocytic tumor
2
glioblastoma multiforme
2
see Figure 2, page 879
DNA Index Characterization
Definition
Histogram Type
Points for Score
0.90 to 1.15
diploid
I
2
1.40 to 1.60
triploid
II
2
1.90 to 2.20
tetraploid
III
2
1.16 to 1.39
hyperdiploid
IV
2
1.61 to 1.89
hypertriploid
V
1
2 non-diploid types
polymorphic
VI
2
see Table 1, page 878, and Figure 3, page 880
where:
• The DNA index characterization is the value of the DNA index from the major G0-G1 DNA peak.
prognostic score =
= (0.0266 * (patient's age in years)) + (1.1618 * (histolopathologic grade)) + (1.3418 * (points for DNA histogram))
A prognostic score of 2.93 correlates with a good prognosis.
A higher score has a worse prognosis. This risk for this patient relative to the good prognosis patient is:
comparative greater risk =
= EXP(patient's score) / EXP(2.93)
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