Description

The response to therapy of HIV-infected patients with Pneumocystis carinii pneumonia (PCP) can be assessed using a severity score based on clinical findings.


Patient selection:

(1) Diagnosis of pneumocystis pneumonia made on bronchoalveolar lavage (BAL).

(2) Patients with severe pneumonia (PaO2 < 50 mm Hg) were excluded.

(3) Interval for determining survival: 45 days

 

Parameter

Finding

Points

respiratory rate

<= 16 per minute

0

 

17-22 per minute

2

 

23-28 per minute

4

 

29-39 per minute

6

 

>= 40 per minute

8

cough

none

0

 

mild; coughing less than 1 time in 15 minutes

1

 

moderate; coughing 1 time every 5-15 minutes; cough interferes with sleep

2

 

severe; constant; coughing 1 or more times every 5 minutes; interferes with both conversation and sleep

3

chest tightness

none

0

 

mild

1

 

moderate; present but does not interfere with daily activities

2

 

constant; noticeable with every breath; interferes with conversation

3

dyspnea

none

0

 

forced to slow walking pace

2

 

forced to interrupt walking

4

 

forced to stop every few minutes or after about 9 meters

6

 

breathlessness with dressing or undressing

8

 

breathlessness at rest

10

supplemental oxygen

none required for comfort

0

 

FIO2 22-30%

2

 

FIO2 31-40%

4

 

FIO2 41-50%

6

 

FIO2 > 50%

8

 

mechanical ventilation

8

fever

< 37.6 °C

0

 

37.6 to 38.5 °C

2

 

38.6 to 39.5 °C

4

 

> 39.5 °C

6

chest radiograph on entry

normal

0

 

abnormal

6

chest radiograph on follow-up

changes resolved

0

 

improvement since entry

3

 

worsening since entry

9

 

PCP score =

= SUM(points for all parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 53

 

Day of Therapy

PCP Score in Survivors at 45 days

PCP Score in Nonsurvivors at 45 days

0

19.3 (SD 6.6)

24.6 (SD 5.6)

3

16.0 (SD 5.6)

23.4 (SD 8.4)

7

11.8 (SD 6.7)

18.0 (SD 6.5)

14

6.8 (SD 3.8)

20.5 (SD 4.4)

 


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